Pipeline

Complex Diseases Require Multiple Routes of Attack

IMV’s current clinical strategy focuses on combination immuno-oncology therapies incorporating our lead therapeutic candidate, DPX-Survivac, for advanced ovarian cancer and diffuse large B-cell lymphoma (DLBCL). Both of these tumor types are associated with poor outcomes and are thus high unmet medical needs.

We are currently engaged in multiple immunotherapy clinical trials leveraging DPX-Survivac and metronomic cyclophosphamide with Merck’s currently marketed anti-PD-1 drug, pembrolizumab, across multiple indications. In addition, we are also evaluating the potential of DPX-Survivac as a monotherapy for certain ovarian cancer patients.

Our clinical program focuses on broadening the utility of next-generation immunotherapies among patient populations with few treatment options.

Our goal with these programs is to confirm preliminary observations that DPX-Survivac may increase the vulnerability of these hard-to-treat tumors, while improving the utility of anti-cancer activity of these advanced agents.

Early clinical investigation of a second agent, DPX-E7, in human papillomavirus (HPV) cervical cancer is being pursued in an academic collaboration led by the Dana-Farber Cancer Institute.

Our ongoing clinical trials currently include:

Recurrent Ovarian Cancer
Study of DPX-Survivac  Therapy and Epacadostat in Patients With Recurrent Ovarian Cancer
ClinicalTrials.gov listing

Recurrent Survivin-Expressing DLBCL
Phase 2 Study of DPX-Survivac, Pembrolizumab and Cyclophosphamide in Patients With Recurrent Survivin-Expressing DLBCL
ClinicalTrials.gov listing

Advanced Ovarian, Primary Peritoneal or Fallopian Tube Cancer
Phase 2 Study of Pembrolizumab, DPX-Survivac and Cyclophosphamide in Advanced Ovarian, Primary Peritoneal or Fallopian Tube Cancer
ClinicalTrials.gov listing

Incurable HPV 16-Related Oropharyngeal, Cervical And Anal Cancer
Trial To Test Safety And Efficacy Of Vaccination For Incurable HPV 16-Related Oropharyngeal, Cervical And Anal Cancer
ClinicalTrials.gov listing

High Standards. Even Higher Aspirations.

Working at IMV brings you to the forefront of cutting-edge science and research for cancer and other serious diseases. We’ve worked hard to build a culture of innovation and collaboration.

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