We have collaborations with world-class organizations and institutions at various stages of the R&D spectrum. Our clinical-stage partnerships focus on assessing optimal combinations of our drug candidates with other novel immuno-modulatory agents, as well as establishing the necessary safety and immunogenicity profiles of our clinical vaccine applicants. Our preclinical collaborations are aimed at generating supportive data to guide a potential future clinical path. We are also evaluating licensing opportunities with DPX-based therapeutic vaccines in other hard-to-treat diseases.
Our ongoing collaboration with Incyte Corporation (Nasdaq: INCY) includes our ongoing Phase 1b clinical trial to evaluate the combination of our lead candidate, DPX-Survivac, with Incyte’s IDO1 inhibitor epacadostat (INCB24360) and low-dose cyclophosphamide in patients with advanced ovarian cancer.
An investigator-sponsored, Phase 2 clinical trial is evaluating our lead candidate, DPX-Survivac, with Merck’s checkpoint inhibitor, pembrolizumab, and low dose cyclophosphamide in patients with advanced ovarian cancer.
We are currently working with Dana-Farber Cancer Institute (DFCI) on a Phase 1b/2 clinical study evaluating our immuno-oncology candidate DPX-E7 in combination with low-dose cyclophosphamide in patients with incurable oropharyngeal, cervical and anal cancers related to the human papillomavirus (HPV). DFCI is leading the study through a $1.5 million research grant from Stand Up To Cancer and the Farrah Fawcett Foundation
Our collaboration with UConn Health focuses on our DPX-NEO program. In preclinical studies, we demonstrated positive anti-cancer and immunogenic activity of patient-specific neoepitopes formulated in our DepoVax therapeutic vaccine platform. We are currently evaluating future clinical paths for this exciting opportunity, considered by some researchers as ‘the next frontier’ in personalized cancer immunotherapies.
Our collaboration with Peregrine aims to determine the potential synergistic effects of combining our lead candidate DPX-Survivac with bavituximab, Peregrine’s investigational chimeric monoclonal antibody that targets phosphatidylserine (PS.) Preclinical research demonstrated that PS-targeting antibodies can enhance the anti-cancer activity of its DepoVax-based therapeutic vaccine platform.
We have a multi-faceted collaboration with Leidos to explore potential applications of DepoVax-based vaccines in some of the world’s most dangerous infectious diseases. Current preclinical research projects are evaluating potential uses in the Zika virus and malaria.
We established a collaboration with CIIE to assess the potential for DepoVax-based vaccines to affect the most virulent form of malaria. Preclinical research demonstrated that CIIE-identified targets, when formulated in the DepoVax targeting platform, generated strong, sustained, antibody responses that could prevent, after a single injection, the process of malaria that is most likely to result in death.
IMV has a long-standing partnership with Zoetis (formerly Pfizer Animal Health) to use the Company’s vaccine delivery technology to develop enhanced cattle vaccines.
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