One of our greatest hopes for advancing the fight against serious diseases is finding better ways to direct our single greatest weapon–the human immune system. But how can we better activate and direct the immune system to serve this purpose?
Our technology provides the foundation of our Company and underscores the novel benefits of our product candidates across multiple therapeutic markets. Our human immune system is bombarded with countless messages and directives at any given moment. The key, we believe, is making sure that the right directives get through, safely and efficiently, to help our body do what it is already designed to do: fight serious diseases.
The technology behind our unique delivery platform can help to get the messages across, by promoting the active uptake and extending the delivery time to the immune system. Our formulations provide a simple but elegant solution to delivering the right messages, and helping to make sure they are received and acted upon, by our immune system.
Through partnerships with pharmaceutical and biotech leaders, we are leveraging the unique capabilities of the platform to develop innovate therapies with the potential to mobilize the power of the immune system in a more rapid, robust and sustained fashion. We work with a sense of purpose, using the best science and drug development practices to address urgent unmet medical needs in cancer and other diseases.
With three candidates already in clinical trials and several more at the precipice, we are committed to building a company that can deliver value for our shareholders, patients and communities.
Using our robust and scalable delivery platform, we develop immunotherapeutic agents that activate and direct T cells against cancer, and complement the activity of other immuno-modulating agents. Our lead candidate, DPX-Survivac, targets the protein survivin, which is present in more than 15 types of solid tumor and hematologic cancers. In addition to being a widely recognized tumor-associated antigen (TAA), survivin also plays an important role in the dysregulated cell apoptosis and metastasis that are the hallmarks of cancer. Therefore, the value of manipulating this target is twofold: it is both a cell surface marker widely expressed in, but specific to, tumor cells, as well as a cancer-driving mechanism that is implicated in the proliferation of the tumor itself.
DPX-Survivac is currently being evaluated in multiple clinical trials in advanced ovarian cancer, one of our main areas of therapeutic focus.
While our internal clinical program is focused on advancing applications of DPX-Survivac in hard-to-treat cancers, we also recognize that our platform has a broad range of applications across multiple therapeutic areas and potential products.
Beyond the cancer market, we are focused on working with partners to deploy our platform in those areas where its novel MOA can deliver the greatest value.